Sewickley is thought to be a Native American word meaning "sweet water." Historians dispute if Native Americans were referring to the Ohio River as the "sweet water" or instead to the syrup derived from a local abundance of maple trees.

Former Pittsburgh Penguins star Mario Lemieux, as well as current Penguins stars Sidney Crosby and Evgeni Malkin, Penguins assistant coach and former player Sergei Gonchar, retired Pittsburgh Steeler legend Franco Harris live in Sewickley, as well as former Steelers Quarterback Mike Tomczak. Lynn Swann is often thought to be a Sewickley resident, but lives in the neighboring borough of Sewickley Heights. Actor and former MTV VJ Dan Cortese and longtime NFL head coach legend Chuck Noll lived here, as well as former Penguins goalie Tom Barrasso. Musician William Fitzsimmons also hails from the borough. The U.S. Representative for Pennsylvania's 12th district, Keith Rothfus, lives in Sewickley. Former NFL head coach Chuck Knox was born and raised in Sewickley. Broadway and film star Caitlin Clarke lived in Sewickley since the age of 10... Wikipedia